[96497] in Discussion of MIT-community interests
Mark Cuban and Lori make a record investment - SHARK TANK
daemon@ATHENA.MIT.EDU (Rubi)
Tue Mar 28 09:33:46 2017
Date: Tue, 28 Mar 2017 09:19:27 -0400
From: Rubi <rubi@tuesdaydietspecial.com>
To: <mit-talk-mtg@charon.mit.edu>
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By Amrutha Penumudi and Natalie Grover
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<span class="articleLocatio</span>n">Oct 23 (Reuters) - An independent panel of advisers to the U.S. Food and Drug Administration on Friday voted 10-4 in favor of approving AstraZeneca Plc' s gout drug.</span>
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All 10 who backed the drug, lesinurad, qualified their vote by urging the FDA to ask AstraZeneca for studies after the drug' s launch to gauge its long-term effectiveness and safety.
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Gout is a form of arthritis in which excess uric acid forms crystals in joints and other tissues, causing painful inflammation.
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AstraZeneca said, if approved, lesinurad will be the first in 60 years to address inefficient excretion in gout patients.
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The panel' s recommendation follows an FDA staff review on Wednesday, which raised questions about the drug' s benefit-risk profile, specifically related to increased cardiovascular and renal risks.
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<td> <span style="font-size: 14px; padding: 0px; margin: 0px 0px 10px; line-height: 21px; font-family: arial,helvetica,clean,sans-serif; color: #222222; "><span style="color: #005ea6; ">Home</span> > <span style="color: #005ea6; ">Best Diets</span> > Mayo Clinic Diet</span> </td>
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"The Mayo Clinic Diet" Recipe Available (Monday Only)
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<span style="font-size: 17px; background-color: #fff800; ">(Voted #1 Recipe for Fat loss by US News 2017)</span>
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A majority of voting FDA panel members agreed lesinurad' s benefit was modest, but meaningful. Those who voted against approval said the drug' s safety profile precluded their support.
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<td> <p style="font-size:18px; display:inline; line-height:21px; height:auto; color:#222222; margin-bottom:10px; font-family:arial,helvetica,clean,sans-serif; "> <strong>US News</strong> - Mayo Clinic Released his famous recipe containing "super-fruits" <a href="http://www.tuesdaydietspecial.com/milkers-braining/cf68_6ZdrobONt16ShvVdVKyxdhVtFMuKmji0hvV0ONWc16" style="color: #005ea6; "><span style="color: #005ea6; ">that kill obesity in record time.</span></a> </p> </td>
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<strong>Scorecard: <a href="http://www.tuesdaydietspecial.com/milkers-braining/cf68_6ZdrobONt16ShvVdVKyxdhVtFMuKmji0hvV0ONWc16" style="color: #005ea6; ">Mayo Clinic Diet</a></strong>
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The FDA usually follows the panel' s recommendations, but is not obligated to do so when it convenes to make its decision on approving a drug.
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<td style="width: 55%; "> <span style="color: #e6c05a; ">â?? â?? â?? â?? â??</span> </td>
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<td style="font-family:arial,helvetica,clean,sans-serif; border-collapse:collapse; line-height:18px; color:#222222; font-size:14px; display:table-cell; "> Fat Loss <strong>Short-term</strong> </td>
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<td style="font-family:arial,helvetica,clean,sans-serif; border-collapse:collapse; line-height:18px; color:#222222; font-size:14px; display:table-cell; "> Easy to Follow </td>
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<td style="font-family:arial,helvetica,clean,sans-serif; border-collapse:collapse; line-height:18px; color:#222222; font-size:14px; display:table-cell; "> Safety </td>
<td> <span style="color: #e6c05a; ">â?? â?? â?? â?? â??</span> </td>
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<td style="font-family:arial,helvetica,clean,sans-serif; border-collapse:collapse; line-height:18px; color:#222222; font-size:14px; display:table-cell; "> For Diabetes </td>
<td> <span style="color: #e6c05a; ">â?? â?? â?? â?? â??</span> </td>
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<td style="font-family:arial,helvetica,clean,sans-serif; border-collapse:collapse; line-height:18px; color:#222222; font-size:14px; display:table-cell; "> For Heart Health </td>
<td> <span style="color: #e6c05a; ">â?? â?? â?? â?? â??</span> </td>
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<td colspan="2" style="font-family:arial,helvetica,clean,sans-serif; border-collapse:collapse; line-height:18px; color:#222222; font-size:12px; display:table-cell; " align="center"> Scores are based on <a href="http://www.tuesdaydietspecial.com/milkers-braining/cf68_6ZdrobONt16ShvVdVKyxdhVtFMuKmji0hvV0ONWc16" style="color: #005ea6; ">experts' reviews</a> </td>
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<td rowspan="2" style="background-color:#026BA6; " valign="top"> <a href="http://www.tuesdaydietspecial.com/milkers-braining/cf68_6ZdrobONt16ShvVdVKyxdhVtFMuKmji0hvV0ONWc16"><img alt="" src="http://www.tuesdaydietspecial.com/13d7aDveT0VB16ihvVdVKyxdhVtFMuKmji0hvV0ONWd04/appointments-worldliness" height="392" width="260" /></a> </td>
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<td> <p style="font-size:19px; display:inline; line-height:21px; height:auto; color:#222222; margin-bottom:10px; font-family:arial,helvetica,clean,sans-serif; "> <strong>VEREDIT: We've tried this Drink</strong> It's super simple to make and very tasty! <a href="http://www.tuesdaydietspecial.com/milkers-braining/cf68_6ZdrobONt16ShvVdVKyxdhVtFMuKmji0hvV0ONWc16" style="color: #005ea6; ">You will see dramatic results in days.</a> </p> </td>
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Ardea said on Friday that the drug was not intended as a first-line treatment for gout, but the drug' s benefit-risk profile was positive enough for approval as an add-on therapy.
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Many patients do not reach target uric acid levels despite using current treatments, creating the need for effective additional therapies such as lesinurad, Ardea said.
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<td align="center"> <p style="font-size:19px; display:inline; line-height:21px; height:auto; color:#222222; margin-bottom:10px; font-family:arial,helvetica,clean,sans-serif; "> <strong>(Drink once in the morning)</strong> and Get rid of all that extra Fat in days </p>
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<td style="width: 494px; "> <p style="text-align: center; "> <a href="http://www.tuesdaydietspecial.com/milkers-braining/cf68_6ZdrobONt16ShvVdVKyxdhVtFMuKmji0hvV0ONWc16" style="border:1px solid #d6d6d6; border-image-slice:100%; border-bottom-left-radius:4.19999980926514px; padding-bottom:8.39999961853027px; letter-spacing:0.280000001192093px; font-size:21px; padding-top:8.39999961853027px; padding-left:14px; border-image-outset:0px; border-top-left-radius:4.19999980926514px; background-color:#090; font-family:arial,helvetica,clean,sans-serif; border-image-width:1; text-decoration:none; color:#FFF; height:40px; box-sizing:border-box; padding-right:14px; border-image-source:none; border-image-repeat:stretch; cursor:auto; border-bottom-right-radius:4.19999980926514px; line-height:14px; border-top-right-radius:4.19999980926514px; display:block; width:494px; ">View Recipe Here - Only Today At "NO COST"</a> </p> </td>
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The current standard of care for gout is an oral drug called allopurinol, which is known to have rare but potentially fatal adverse effects involving skin.
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AstraZeneca' s shares were up just under 1 percent at $31.36 in late afternoon trading. (Reporting by Amrutha Penumudi and Natalie Grover in Bengaluru; Editing by Savio D' Souza)
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