[88159] in Discussion of MIT-community interests
Trump Calls Out Shocking Scandal
daemon@ATHENA.MIT.EDU (US Domino)
Tue Sep 6 07:21:24 2016
Date: Tue, 6 Sep 2016 13:12:45 +0200
From: "US Domino" <US-Domino@dommino.bid>
Reply-To: "US Domino" <US-Domino@dommino.bid>
To: <mit-talk-mtg@charon.mit.edu>
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Trump Calls Out Shocking Scandal
http://dommino.bid/TSEqoWcSztYliVTByNiKvQWUbcxLSuzSJ4LlrevJ0C4
Trump Calls Out Shocking Scandal
to re-move
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Important cell types involved in cancer growthThere are several different cell types that are critical to tumor growth. In particular endothelial progenitor cells are a very important cell population in tumor blood vessel growth. This finding was demonstrated in the high impact factor journals of Science (2008) and Genes and Development (2007), which also showed that Endothelial Progenitor Cells are critical for metastasis and the angiogenesis. This importance of endothelial progenitor cells in tumour growth and angiogenesis has been confirmed by a recent publication in Cancer Research (August 2010). This seminal paper has demonstrated that endothelial progenitor cells can be marked using the Inhibitor of DNA Binding 1 (ID1). This novel finding meant that investigators were able to track endothelial progenitor cells from the bone marrow to the blood to the tumour-stroma and even incorporated in tumour vasculature. This finding of endothelial progenitor cells incorporated in tumour vasculature proves the importance of this cell type in blood vessel development in a tumour setting. Furthermore, ablation of the endothelial progenitor cells in the bone marrow lead to a significant decrease in tumour growth and vasculature development. Therefore, endothelial progenitor cells are very important in tumour biology and present novel therapeutic targets.
In vitro research using cell linesElectroporation is used extensively in cancer research for gene and drug delivery. Gemini X2 system manufactured by BTX Harvard ApparatusIn vitro assays allow scientists to conduct studies under reasonable conditions in the lab. To study the communication between a tumor cell and a host cell, scientists have created in vitro assays. The use of fragmented chicken heart cells as a host case for nutrients Thus allowing the HeLa cells to, in a sense win, and over take the PHF. In the case of the L tumor cells, they were not able to invade the PHF. Though HeLa cells were able to accomplish invasion after several hours the L cells are structurally different rendering them inadequate. The L cells have much more intercellular free space and do not surround the host cell as tightly as Hela cells. It was concluded that with a tight gap junction nutrients cannot enter the cell allowing the cancer cells to invade. With this information about the gap junction process between host cell and the tumor cell, further studies were conducted in cancer gene therapy with the use of Hela cells and the herpes virus.
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