[88151] in Discussion of MIT-community interests
Online Quiz - is a reverse mortgage right for you
daemon@ATHENA.MIT.EDU (Reverse Mortgage Quiz)
Tue Sep 6 05:57:27 2016
Date: Tue, 6 Sep 2016 11:57:19 +0200
From: "Reverse Mortgage Quiz" <Reverse-Mortgage-Quiz@morett.bid>
Reply-To: "Reverse Mortgage Quiz" <Reverse-Mortgage-Quiz@morett.bid>
To: <mit-talk-mtg@charon.mit.edu>
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Online Quiz - is a reverse mortgage right for you
http://morett.bid/pWeNyxKdbPgXPM4qSuqdswDqx4tEnaQUSL7mFaDbL63rxajV
Online Quiz - is a reverse mortgage right for you
to re-move
http://morett.bid/HlO1skJVMeIsk2BcepGx0mz0vJYskAwDzeG8eq8_Tvmp5MNb
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<!-----Early research on the cause of cancer was summarized by Haddow in 1958. The first chemical carcinogen was identified in 1928-29 as 1:2-5:6-dibenzanthracene, and the carcinogeneic substance in pitch was identified as 3:4-benzopyrene in 1933. Haddow concluded that “there can be little doubt of the importance of their combination with the genetical material” as the source of the chemical mechanism of action of carcinogens. Brookes and Lawley, in 1964, summarized ongoing research into the causes of cancer. They referred to the competing hypotheses that carcinogens reacted mainly with proteins versus mainly with DNA. The direct research of Brookes and Lawley, testing carcinogenic hydrocarbons, indicated that they react with DNA. McCann et al. in 1975 and McCann and Ames, in 1976, tested 175 known carcinogens for interaction with DNA sufficient to cause mutations in their new Salmonella/microsome test. This test uses bacteria as sensitive indicators of DNA damage. They found that 90% of known carcinogens caused mutations in their test. They indicated that the carcinogens that did not cause mutations in their assay were likely due to the need for the carcinogens to be activated by enzymes not available in their system.By 1981, Doll and Peto had conducted an epidemiological study in which they compared cancer rates for 37 specific cancers in the United States to rates for these cancers in populations where the incidence of these cancers is low. The populations compared with US populations included Norwegians, Nigerians, Japanese, British, and Israeli Jews. Their conclusion was that 75 - 80% of the cases of cancer in the United States were likely avoidable. The avoidable sources of cancer included tobacco, alcohol, diet (especially meat and fat), food additives, occupational exposures (including aromatic amines, benzene, heavy metals, vinyl chloride), pollution, industrial products, medicines and medical procedures, UV light from the sun, exposure to medical x-rays, and infection. Many of these sources of cancer are DNA damaging agents.More recent research, indicating both the role of DNA damage in causing cancer and other factors including reduced expression of DNA repair genes by epigenetic alterations (allowing DNA damages to accumulate) are summarized in Carcinogenesis and in an article by Bernstein et al. in 2013.
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