[50474] in Discussion of MIT-community interests
Treat Your Psoriasis
daemon@ATHENA.MIT.EDU (Psoriasis Miracle)
Wed Aug 19 06:07:09 2015
Date: Wed, 19 Aug 2015 06:07:07 -0400
To: mit-talk-mtg@charon.mit.edu
From: Psoriasis Miracle <psoriasismiracle@careatmost.org>
Reply-to: Psoriasis Miracle <psoriasismiracle@careatmost.org>
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Treat Your Psoriasis
r classes of human C-fibre nociceptors exist: mechano-responsive nociceptors and mechano-insensitive nocice
ptors. M 4echano-responsive nociceptors have been s 18h4 yhown in studies to respond to mostly pain, and mechano-inse
nsitive receptors respond mostl 8h4 y to itch induced by histamine. However, it does 8h4 ynot explain mechanically ind
Studies have been done to show that itch receptors are found only on the top two skin layers, the epidermis a
nd the epidermal/dermal transition layers.[ci h4tation needed] Shelley and Arthur had verified the depth by inje
cting individual itch powder spicules (Mucuna pruriens), and found that h4emaximal sensitivity was found at the
basal cell layer or the innermost layer of the epidermis. Surgical removal of those skin layers removed the
ability for a patien 4et to perceive itch.[citation needed] Itch is never felt in 8h4 ymuscle or joints, which strong
ly suggests that deep tissue probably does not contain i h4tch signaling apparatuses.
Sensitivity to pruritic stimuli is evenl 8h4 yy distributed across the skin, and has a clear spot distribution with
similar density to 8h4 ythat of pain. The different substances that elicit itch upon intracutaneous injection (inj
ection within the skin) elicit only pain
input to the spinal cord is known to produce central sensitization, which consists of allodynia, exaggerati
on of pain, and punctuate hyperalgesia, extr h4eme sensitivity to pain. Two types of mechanical hyperalgesia c
an occur: 1) touch that is normally painless in the uninjured surroundings of a cut h4 or tear can trigger pain
ful sensations ( h4ouch-evoke 4ed hyperalgesia), and 8h4 y a slightly painful pin prick stimulation is perceived as m
ore painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requir
es continuo 8h4 yus firing of primary afferent nociceptors, a 18h4 nd punctuate hyperalgesia does not require continuous f
iring which means it can persist for hours a 8h4 yfter a trauma and can be str 4eonger than normally experienced. In
addition, it was found that h4 patients with neuropathic pain, histamine ionophoresis resulted in a sensation
of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spin
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r classes of human C-fibre nociceptors exist: mechano-responsive nociceptors and mechano-insensitive nocice
ptors. M oechano-responsive nociceptors have been s uxwo yhown in studies to respond to mostly pain, and mechano-inse
nsitive receptors respond mostl xwo y to itch induced by histamine. However, it does xwo ynot explain mechanically ind
Studies have been done to show that itch receptors are found only on the top two skin layers, the epidermis a
nd the epidermal/dermal transition layers.[ci wotation needed] Shelley and Arthur had verified the depth by inje
cting individual itch powder spicules (Mucuna pruriens), and found that woemaximal sensitivity was found at the
basal cell layer or the innermost layer of the epidermis. Surgical removal of those skin layers removed the
ability for a patien oet to perceive itch.[citation needed] Itch is never felt in xwo ymuscle or joints, which strong
ly suggests that deep tissue probably does not contain i wotch signaling apparatuses.
Sensitivity to pruritic stimuli is evenl xwo yy distributed across the skin, and has a clear spot distribution with
similar density to xwo ythat of pain. The different substances that elicit itch upon intracutaneous injection (inj
ection within the skin) elicit only pain
input to the spinal cord is known to produce central sensitization, which consists of allodynia, exaggerati
on of pain, and punctuate hyperalgesia, extr woeme sensitivity to pain. Two types of mechanical hyperalgesia c
an occur: 1) touch that is normally painless in the uninjured surroundings of a cut wo or tear can trigger pain
ful sensations ( woouch-evoke oed hyperalgesia), and xwo y a slightly painful pin prick stimulation is perceived as m
ore painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requir
es continuo xwo yus firing of primary afferent nociceptors, a uxwo nd punctuate hyperalgesia does not require continuous f
iring which means it can persist for hours a xwo yfter a trauma and can be str oeonger than normally experienced. In
addition, it was found that wo patients with neuropathic pain, histamine ionophoresis resulted in a sensation
of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spin
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